Diazoxide (Proglycem®)
What is diazoxide?
Diazoxide is a prescription medicine used to help prevent low blood sugar (hypoglycemia).
It is commonly used in children with conditions such as:
- Congenital hyperinsulinism
- Other causes of low blood sugar related to too much insulin
Diazoxide works by helping the body release less insulin. This helps keep blood sugar from dropping too low.
Why is blood sugar important?
Blood sugar gives the body energy. The brain especially needs a steady amount of sugar to work properly.
Low blood sugar can cause symptoms such as:
- Shaking
- Sweating
- Hunger
- Sleepiness
- Irritability
- Seizures
Keeping blood sugar in a safe range is very important for growing children.
How is diazoxide taken?
Diazoxide is:
- Taken by mouth as a liquid or capsule
- Usually given 2 to 3 times each day
- Often given with food
Give the medicine exactly as prescribed by your child’s provider.
Your child may also need regular blood sugar checks at home.
What if my child misses a dose?
If you miss a dose:
- Give it as soon as you remember
- If it is almost time for the next dose, skip the missed dose
- Do not give two doses at the same time
Call your healthcare provider if you are unsure what to do.
What are common side effects?
Many children tolerate diazoxide well. Common side effects may include:
- Increased hair growth
- Nausea
- Decreased appetite
- Swelling of the hands, feet, or face
- Fluid retention
- Changes in blood sugar levels
Some children may also gain weight due to fluid retention.
When should I call the doctor?
Call your child’s healthcare provider if your child has:
- Trouble breathing
- Severe swelling
- Rapid weight gain
- Feeding problems
- Vomiting
- High blood sugar symptoms, such as increased thirst or urination
- Fast heartbeat
- Severe sleepiness
Get emergency help right away for seizures, severe breathing problems, or if your child is difficult to wake up.
Important safety information
Your child may need:
- Regular blood sugar monitoring
- Blood tests
- Heart and breathing checks
- Monitoring for fluid retention
Some children taking diazoxide may also need a diuretic (“water pill”) to help prevent extra fluid buildup.
Tell your child’s provider about all medicines your child takes.
Tips for families
- Give the medicine at the same times each day
- Monitor blood sugars as directed
- Keep a record of blood sugar readings
- Keep follow-up appointments
- Have a plan for treating low blood sugar emergencies
Your endocrinology team will help you learn how to safely manage your child’s blood sugar.
Questions?
If you have questions about diazoxide, contact your pediatric endocrinology team at Endo For Kids.
