Crysvita® (burosumab-twza)
What is Crysvita?
Crysvita is a prescription medicine used to treat certain rare conditions that affect bone growth and phosphate levels in the body.
It is most commonly used for:
- X-linked hypophosphatemia (XLH)
- Some other rare phosphate-wasting disorders
Crysvita helps the body hold onto phosphate, which is important for strong bones and healthy growth.
What is phosphate?
Phosphate is a mineral that helps:
- Build strong bones and teeth
- Support muscle function
- Provide energy for the body
Children with low phosphate levels may have:
- Bone pain
- Weak bones
- Slow growth
- Bowed legs
- Trouble walking
Crysvita helps increase phosphate levels to support healthier bones and growth.
How is Crysvita given?
Crysvita is:
- Given as a shot under the skin
- Usually given every 2 weeks in children
- Given by a healthcare provider or trained caregiver
Common injection sites include:
- Upper arms
- Thighs
- Stomach
- Buttocks
Your child’s endocrinology team will decide the correct dose and schedule.
What are common side effects?
Many children tolerate Crysvita well. Common side effects may include:
- Redness or pain at the injection site
- Headache
- Fever
- Arm or leg pain
- Tooth pain
- Muscle aches
- Dizziness
Most side effects are mild.
When should I call the doctor?
Call your child’s healthcare provider if your child has:
- Severe bone or muscle pain
- Trouble walking
- Severe headache
- Rash or swelling
- Trouble breathing
- Signs of an allergic reaction
- New or worsening weakness
Get emergency help right away for severe allergic reactions or breathing problems.
Important safety information
Your child will need regular:
- Blood tests
- Phosphate level monitoring
- Growth checks
- Bone health monitoring
Do not give oral phosphate or certain vitamin D medicines unless your provider tells you to.
Tell your healthcare provider about all medicines and supplements your child takes.
Tips for families
- Keep all lab and clinic appointments
- Track your child’s growth and symptoms
- Follow the injection schedule closely
- Report new bone pain or walking problems
Treatment can help improve bone strength, growth, and overall comfort over time.
Questions?
If you have questions about Crysvita, contact your pediatric endocrinology team at Endo For Kids.
