Skytrofa® (lonapegsomatropin)
What is Skytrofa?
Skytrofa is a prescription growth hormone medicine. It is used to help children who do not make enough natural growth hormone grow better.
Skytrofa is a long-acting growth hormone. This means it is given once a week instead of every day.
What is growth hormone?
Growth hormone is made by a small gland in the brain called the pituitary gland. It helps children:
- Grow taller
- Build muscles and bones
- Keep a healthy amount of body fat
- Have normal energy levels
Some children do not make enough growth hormone. This is called growth hormone deficiency.
How is Skytrofa given?
Skytrofa is:
- Given as an injection (shot) under the skin
- Usually given once every week
- Given on the same day each week
Common places for the injection include:
- Stomach
- Thighs
- Upper arms
- Buttocks
It is important to rotate injection sites to help prevent skin irritation.
Your child’s endocrinology team will teach you how to give the medicine safely.
How should Skytrofa be stored?
- Keep Skytrofa in the refrigerator
- Store it in the original carton to protect it from light
- Do not freeze it
- Keep it out of reach of children
Follow the pharmacy instructions carefully.
What are common side effects?
Many children do well on Skytrofa. Some may have mild side effects, including:
- Redness or pain where the shot was given
- Headache
- Muscle or joint pain
- Swelling of hands or feet
- Tiredness
- Nausea
These side effects are often mild and improve over time.
When should I call the doctor?
Call your child’s healthcare provider if your child has:
- Severe headaches
- Vision changes
- Trouble breathing
- Severe swelling
- Hip or knee pain
- Limping
- Severe stomach pain
- Signs of an allergic reaction such as rash, swelling, or trouble breathing
Seek emergency help right away for serious breathing problems or severe allergic reactions.
Important safety information
Tell your child’s provider if your child has:
- Diabetes
- Scoliosis
- Sleep apnea
- Cancer history
- Severe illness or recent surgery
Your child will need regular follow-up visits and blood tests while taking Skytrofa.
Tips for families
- Give the medicine on the same day each week
- Mark injection days on a calendar
- Keep all endocrinology appointments
- Track your child’s height and growth
Growth can take time. Many children need treatment for several years.
Questions?
If you have questions about Skytrofa, contact your pediatric endocrinology team at Endo For Kids.





